Researchers of the Neurobiology and Neurophysiology team of the Medicine Faculty at Valencia Catholic University (UCV), headed by Jorge Bacia, have discovered that exosomes – microscopic extracellular vesicles that are released by all cells...
Read More »Improved productive loading onto extracellular vesicles
Extracellular vesicles are promising delivery vesicles for therapeutic RNAs. Small interfering RNA (siRNA) conjugation to cholesterol enables efficient and reproducible loading of extracellular vesicles with...
Read More »Researchers invent novel RNA nanotech to decorate exosomes for effective cancer therapy
Therapies based on RNA, such as small interfering RNA, hold great promise for cancer treatment but delivering these agents to their targets in cancer...
Read More »siRNA in milk exosomes is resistant to digestion and cross intestinal barrier in vitro
Milk is not only a composite of nutrients but emerged as a source of exosomes acting as a promising drug delivery vehicle for siRNA. siRNA is known for its immense therapeutic potential but has various physiological limitations including stable delivery. ...
Read More »Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles
Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles that mediate intercellular communication by transferring biomolecules, including proteins and RNA, between cells. As a result of their suggested natural capability to functionally deliver RNA, EVs may be harnessed as therapeutic RNA carriers. ...
Read More »Exosomes as an siRNA delivery vehicle
Researchers from the University of Palermo (Italy) generated targeted exosomes able to deliver Imatinib or BCR-ABL siRNA to CML cells in order to overcome pharmacological resistance. The benefit of using exosomes as a drug delivery system lies in the fact that ...
Read More »Exosomes – Nanoparticulate Tools for RNA Interference and Drug Delivery
Exosomes are naturally occurring extracellular vesicles released by most mammalian cells in all body fluids. Exosomes are known as key mediators in cell-cell communication and facilitate the transfer of genetic and biochemical information between distant cells. Structurally, exosomes are composed ...
Read More »Functional exosome-mimic for delivery of siRNA to cancer
Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subject of intensive research. Here, researchers from the Ohio State ...
Read More »Researchers deliver siRNA in exosomes to fight Huntington’s disease
Delivery represents a significant barrier to the clinical advancement of oligonucleotide therapeutics for the treatment of neurological disorders, such as Huntington’s disease. Small, endogenous vesicles known as exosomes have the potential to act as oligonucleotide delivery vehicles, but robust and ...
Read More »Exosomes – a new strategy to treat drug relapse and diseases of the central nervous system
Cell-derived exosomes have been demonstrated to be efficient carriers of small RNAs to neighbouring or distant cells, highlighting the preponderance of exosomes as carriers for gene therapy over other artificial delivery tools. In the present study, researchers from Nanjing University employed ...
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