Spinal cord injury (SCI) is one of the most common devastating injuries, which causes permanent disabilities such as paralysis and loss of movement or sensation. The precise pathogenic mechanisms of the disease remain unclear, and, as of yet, there is ...
Read More »Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use
Extracellular vesicles (EVs) derived from stem and progenitor cells may have therapeutic effects comparable to their parental cells and are considered promising agents for the treatment of a variety of diseases. To this end, strategies must be designed to successfully ...
Read More »Exosome-mediated siRNA delivery – a strong candidate to block inflammasome activation
Neuroinflammation is a response against harmful effects of diverse stimuli and participates in the pathogenesis of brain and spinal cord injury (SCI). The innate immune response plays a role in neuroinflammation following central nervous system (CNS) injury via activation of ...
Read More »Circulating microRNAs as biomarkers for evaluating the severity of acute spinal cord injury
Study design: An in vivo study in mouse models of spinal cord contusion. Objectives: To develop a novel indicator to anticipate the severity of spinal cord injury (SCI) during the acute phase and for the assessment of the efficacy of ...
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