In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread to neighboring, recipient cells where the misfolded ...
Read More »Post-doc Position Available – Laboratory of Molecular NeuroTherapeutics
We are looking for highly motivated postdoctoral research fellows with a PhD in molecular biology and neuroscience field awarded within the past three years. These positions will be involved in functional characterization of extracellular vesicles (such as exosomes) in Alzheimer’s ...
Read More »Exosomes and Antibodies Tie Plasma Aβ and Tau to Alzheimer’s
While changes in cerebrospinal fluid Aβ and tau reliably flag the onset of Alzheimer’s disease, plasma levels of these proteins have remained frustratingly uninformative. At the annual Society for Neuroscience conference, held November 12-16 in San Diego, speakers once again ...
Read More »Astrocytes and Exosomes Implicated in Protein Propagation
Alzfoum – Many researchers now believe that misfolded proteins spread from cell to cell across the brain, corrupting normal proteins as they go, yet exactly how this propagation would happen remains unclear. At the Society for Neuroscience annual meeting, held ...
Read More »Post-doc Postion Available – Med Laboratory of Molecular Neurotherapeutics
We are looking for highly motivated postdoctoral research fellows with a PhD in molecular biology and neuroscience field awarded within the past three years. These positions will be involved in functional characterization of extracellular vesicles (such as exosomes) in Alzheimer’s ...
Read More »Exosomes may hold the key to diagnosing brain injuries in NFL players
from Neurology Advisor by Alicia Ciccone Researchers may have uncovered a way to detect chronic traumatic encephalopathy (CTE) in living individuals with a blood test that detects plasma exosomal tau. The preliminary results were published in the Journal of Alzheimer’s ...
Read More »Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Deadly Delivery – Microglia May Traffic Tau Via Exosomes
from Alzforum – Researchers have known for some time that the tau protein wears walking shoes; it can pass between neurons and march across interconnected regions of the brain. Microglial journeymen may facilitate these interneuronal excursions, according to a study ...
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