Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterised by chronic inflammation and significant airflow obstruction that is not fully reversible, and is one of the leading causes of morbidity and mortality worldwide. Extracellular...
Read More »Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs sssociated with insulin sensitivity
There is increasing evidence that miRNAs, which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared to normal pregnancies, gestational diabetes...
Read More »The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer
Chemoresistance is one of the major obstacles in the treatment of cancer patients. It poses a fundamental challenge to the effectiveness of chemotherapy...
Read More »Researchers demonstrate an exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells
It is a well-known phenomenon that cancer cells release key biological information such as DNA, RNA or proteins into body fluids (e.g., blood, urine or saliva). The analysis of these molecules-often encapsulated...
Read More »Exosomes hijack the endosomal pathway to spread to interconnected neurons
In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread to neighboring, recipient cells where the misfolded ...
Read More »Proteomics method to identify protein profiles in exosomes
Exosomes are membrane-bound nanovesicles that transport molecular signals (e.g., proteins) between cells and are released from a wide range of cells, including the human placenta. Interestingly...
Read More »Exosome project to enhance tick resistance in cattle earns government support
Research with the potential to greatly enhance Queensland’s $5 billion per annum beef industry has earned $250,000 funding from the Palaszczuk Government’s Advance Queensland Innovation Partnerships program. Minister for Innovation, Science and the Digital Economy Leeanne Enoch said today (Wednesday) ...
Read More »A method for isolation and enrichment of purified bovine milk exosomes
Exosomes are nanovesicles that play important roles in intercellular communication as they carry information to target cells. Isolation of high purity exosomes will aid in studying the exosomal cargo and quantity as well as how cell-specific messages are carried. Researchers ...
Read More »Characterization of exosomal release in bovine endometrial intercaruncular stromal cells
Cell-to-cell communication between the blastocyst and endometrium is critical for implantation. In recent years, evidence has emerged from studies in humans and several other animal species that exosomes are secreted from the endometrium and trophoblast cells and may play an ...
Read More »Real time and label free profiling of clinically relevant exosomes
Tumor-derived exosomes possess significant clinical relevance due to their unique composition of genetic and protein material that is representative of the parent tumor. Specific isolation as well as identification of proportions of these clinically relevant exosomes (CREs) from biological samples ...
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