Tag Archives: transplant rejection

Sensitization to human leukocyte antigens (HLA) remains a significant immunologic barrier to successful transplantation. Identifying immune mechanisms responsible for antibody-mediated rejection (ABMR) is an important goal. Here researchers at Cedars-Sinai Medical Center explored the possibility of predicting the risk for ...

Immune-mediated rejection of donor tissues is one of the largest challenges in transplant biology. While routine biopsy to monitor transplanted organs can be informative, this procedure is invasive and carries several risks. In this episode, Prashanth Vallabhajosyula and colleagues evaluated ...

Approximately 30,000 organ transplants occur in the United States each year. However, between 20 and 50 percent–depending on the organ type–of the transplanted organs fail within five years, most often because the recipient’s immune system attacks, or “rejects,” the donated ...

The Signature, Derived From a Liquid Biopsy Test, has the Potential to Avoid the Complications of Repeated Needle Biopsies ROTTERDAM, Netherlands–(BUSINESS WIRE)–Exosome Diagnostics, a developer of revolutionary biofluid-based molecular diagnostics, in collaboration with Brigham and Women’s Hospital, in Boston, Mass., ...

Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. Researcher at the Hospital of the University of Montreal used large-scale proteomics, with ...