In order for cancer cells to successfully spread and multiply, they must find a way to avoid the body’s own immune system. Scientists at the German Cancer Research Center (DKFZ) have published an explanation for how this occurs with chronic ...
Read More »Manipulating exosomal content by genetic transfection
Exosomes are responsible for intercellular communication between tumor cells and others in the tumor microenvironment. These microvesicles promote oncogensis and can support towards metastasis by promoting a pro-tumorogenic environment. Modifying the exosomal content and exosome delivery are emerging novel cancer ...
Read More »Extracellular vesicle-mediated modulation of angiogenesis
Angiogenesis is a tightly regulated process where a number of different players are involved. Recently, a role for membrane vesicles actively released from cells has been proposed. Virtually all cell types may release non-apoptotic membrane vesicles in the nano-size range ...
Read More »The Capture and Identification of Circulating DNA and Tumor Cells Is Fueling a Biotech Revolution That Is Longing For Clinical Acceptance
from Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D. The term “biopsy” frequently evokes fear in patients, as the procedure is most often associated with cancer screening. Nevertheless, patient fears about biopsies are not wholly unwarranted and not simply due ...
Read More »M-Trap: Exosome-Based Capture of Tumor Cells as a New Technology in Peritoneal Metastasis
Remodeling targeted tissues for reception of tumor cells metastasizing from primary lesions is a consequence of communication between the tumor and the environment that governs metastasis. This study describes a novel approach that aims to disrupt the process of metastasis ...
Read More »MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer
Cancer-cell communication is an important and complex process, achieved through a diversity of mechanisms that allows tumor cells to mold and influence their environment. In recent years, evidence has accumulated indicating that cells communicate via the release and delivery of ...
Read More »Detection of Internalized Exosomes by Tumor Cells Using Amnis ImageStreamX
Tumor exosomes as circulating biomarkers ?
by Clotilde Théry,PhD, Institut Curie, INSERM U932, Paris exosomes: a subtype of secreted membrane vesicles originating from late endosomes. Plasma membrane – derived vesicles ( ectosomes, microvesicles …)
Read More »Said the tumor to its neighbor, “You’ve got mail”
By Alissa Poh Cells have their own miniaturized postal service in the shape of vesicles, or tiny bubbles through which molecules crucial for biological processes like communication and food intake are sorted, packaged and delivered. Aside from the 2013 Nobel ...
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