Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. Researchers demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, ...
Read More »Role of stem cell-derived exosomes in cancer
Exosomes are small, extracellular membrane- enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, ...
Read More »The Role of Exosomes in Pancreatic Cancer Microenvironment
Exosomes are nanovesicles shed by cells as a means of communication with other cells. Exosomes contain mRNAs, microRNAs (miRs) and functional proteins. In the present paper, researchers from Ohio State and Penn State Universities develop a mathematical model of tumor-immune ...
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