To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years in particular with the...
Read More »Biomarkers of cancer cell-derived extracellular vesicles from liquid biopsies
Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and...
Read More »Extracellular vesicle-mediated nucleic acid transfer and reprogramming in the tumor microenvironment
Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites...
Read More »Extracellular Vesicles and Cancer – A Focus on Metabolism, Cytokines, and Immunity
A better understanding of the mechanisms of cell communication between cancer cells and the tumor microenvironment is crucial to develop...
Read More »Communication in tiny packages – Exosomes as means of tumor-stroma communication
Tumor-derived exosomes are nano-sized vesicles acting as multi-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs, DNA fragments), lipids, proteins and even pharmacological ...
Read More »The Liquid Biopsy – A Snapshot of The Tumor Microenvironment in Colorectal Cancer
The molecular profile of liquid biopsies is emerging as an alternative to tissue biopsies in the clinical management of malignant diseases. In colorectal cancer, significant liquid biopsy-based biomarkers have demonstrated an ability to discriminate between...
Read More »Exosomes role in tumorigenesis and anticancer drug resistance
Exosomes are a class of extracellular vesicles ranging in size from 40 to 100 nm, which are secreted by both cancer cells and multiple stromal cells in the tumor microenvironment. Following their secretion, exosomes partake in endocrine, paracrine and autocrine signaling. ...
Read More »Recent advancements in the study of breast cancer exosomes as mediators of intratumoral communication
Breast cancer is a heterogeneous disease, with a morbidity rate of 27.8% and a mortality rate of 15% among women population worldwide. Understanding how this cancer develops and the mechanisms behind tumor progression and chemoresistance is of utmost importance. Exosomes ...
Read More »Exosomal circRNAs – biogenesis, effect and application in human diseases
Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel member of endogenous noncoding...
Read More »Exosomes and their role in tumor microenvironment and host-tumor “macroenvironment”
Tumor-derived exosomes (TEX) are important intercellular messengers that contribute to tumorigenesis and metastasis through a variety of mechanisms such as immunosuppression and metabolic reprogramming that generate a pre-metastatic...
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