Tag Archives: tumor

Exosomes represent a new generation of biomarkers for the early diagnosis of hepatic carcinoma. Researchers from Tongji Medical College have developed a fluorometric assay that is based on the hybridization chain reaction and magnetic...

Endothelial cells (blue/grey) internalizing exosomes (red) released from chemotherapy-treated tumors Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called ‘neoadjuvant’...

Tumor-derived exosomes (TEXs) are extracellular vesicles that are continuously released into the blood by tumor cells and carry specific surface markers of the original tumor cells. Substantial evidence has implicated TEXs as attractive diagnostic markers for cancer. However, the detection ...

MicroRNAs (miRNAs) constitute a large family of small, approximately 20-22 nucleotide non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Multiple studies report that miRNAs are involved in homeostatic maintenance and that aberrant expression of ...

IMAGE: Tumor suppressor p53 trimer and DNA fragment. Credit: Cho, Y., Gorina, S., Jeffrey, P.D., Pavletich, N.P.; Astrojan. Before a malignant tumor is developed, the immune system tries to fight against proteins that are altered during their formation, producing certain cancer ...

Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including ...

from Oncology Nurse Advisor by Kathy Boltz, PhD Analyzing tumor DNA fragments in the bloodstream, known as circulating tumor DNA (ctDNA), may offer a more complete view of a patient’s cancer from a molecular perspective. These findings were published in ...

Exosomes derived from tumor cells are essential for processes involved in tumor progression, including angiogenesis, tumor cell proliferation and immunoregulation. In addition, exosome secretion may contribute to the mechanisms of hypoxia-induced angiogenesis and metastasis of tumors. In the present study, ...

ImmunoChemistry Technologies In this webinar, learn how escaping immune system surveillance is a major obstacle for immunotherapies against cancer. Tumor cells secrete soluble factors allowing them to escape immune surveillance. Exosomes, or small vesicular structures excreted by normal cells, have ...

from Nature Reviews Cancer by Gemma K. Alderton Why do some cancers only metastasize to certain organs? This question of organotropism is perplexing, and a team led by Lyden, Bromberg and Peinado have found that exosomes could be key. Exosomes ...