Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical validation studies and no clearly defined manufacturing process exist. As exosomes progress towards the clinic for treatment of a vast ...
Read More »Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs
Metabolic changes within the cell and its niche affect cell fate and are involved in many diseases and disorders including cancer and viral infections. Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS). KSHV latently infected cells ...
Read More »Exosomes are powerfully cardioprotective
Exosomes are nanometer-sized vesicles released from cells into the blood, where they can transmit signals throughout the body. Shown to act on the heart, exosomes’ composition and the signaling pathways they activate have not been explored. In this study, researchers ...
Read More »Exosome Post-doc Position Available – Parkinson’s Disease Transmission
Position – Postdoctoral Research Associate to investigate the role of exosomes in Parkinson’s Disease Transmission and design new therapeutic strategies. Institution – University College London, Institute of Neurology, London , UK Applications are invited for a Research Associate within the ...
Read More »Therapeutic potential of RVG-exosome delivery of siRNA
Alpha-synuclein (α-Syn) aggregates are the main component of Lewy bodies, which are the characteristic pathological feature in Parkinson’s disease (PD) brain. Evidence that α-Syn aggregation can be propagated between neurones has led to the suggestion that this mechanism is responsible ...
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