Tag Archives: University of Pennsylvania

University of Maryland School of Medicine study shows the potential of transplanted stem cell secretions as a liquid biopsyStem-cell based therapies to strengthen the heart muscle and treat other diseases are beginning to show promise in...

Tumor-derived extracellular vesicles (TEV) “educate” healthy cells to promote metastases. Researchers from the University of Pennsylvania found that melanoma TEV downregulated type I interferon (IFN)...

Circulating exosomes contain a wealth of proteomic and genetic information, presenting an enormous opportunity in cancer diagnostics. While microfluidic approaches have been used to successfully isolate cells from complex samples, scaling these approaches for exosome isolation has been limited by ...

Approximately 30,000 organ transplants occur in the United States each year. However, between 20 and 50 percent–depending on the organ type–of the transplanted organs fail within five years, most often because the recipient’s immune system attacks, or “rejects,” the donated ...

from Genetic Engineering News – Investigators at the Abramson Cancer Center at the University of Pennsylvania (ACC) have just released data from a new study that suggests a noninvasive liquid biopsy test may be a more efficient and suitable alternative ...

A major impediment to improving the treatment of concussion is our current inability to identify patients that will experience persistent problems after the injury. Recently, brain-derived exosomes, which cross the blood-brain barrier and circulate following injury, have shown great potential ...

Research Specialist A – UPENN – Perelman School of Medicine Duties The Research Specialist will be involved with the study of Molecular biology and donor organ-specific exosome profiles from transplant recipient patients’ blood/bodily fluids which can serve as a novel, ...

Stromal communication with cancer cells can influence treatment response. Researchers at the University of Pennsylvania show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interaction, exosomes are transferred ...

Cilia, organelles that function as cellular antennae, are central to the pathogenesis of “ciliopathies”, including various forms of polycystic kidney disease (PKD). To date, however, the molecular mechanisms controlling ciliogenesis and ciliary function remain incompletely understood. A recently proposed model ...