Extracellular vesicles (EV) are cell-derived lipid bilayer-delimited structures providing an important means of intercellular communication. Recent...
Read More »Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis
Exosomes are nano-sized extracellular vesicles released by many cells that contain molecules characteristic of their cell of origin, including microRNA. Exosomes released by glioblastoma cross the...
Read More »Scientists unlock path to use cell’s own nanoparticles as disease biomarkers
Researchers at the University of Sydney have established a method to identify individual nanoparticles released by human cells, opening...
Read More »Exosomal microRNA signatures in multiple sclerosis reflect disease status
A breakthrough study led by the University of Sydney’s Brain and Mind Centre and Royal Prince Alfred Hospital has revealed unique molecules in the blood of people with Multiple Sclerosis (MS) that could become definitive diagnostic biomarkers of the world’s ...
Read More »Surface Profiling of Extracellular Vesicles Using DotScan Antibody Microarrays
DotScan antibody microarrays were initially developed for the extensive surface profiling of live leukemia and lymphoma cells. DotScan’s diagnostic capability was validated with an extensive clinical trial using mononuclear cells from the blood or bone marrow of leukemia or lymphoma ...
Read More »Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples
Extracellular vesicles (EV) are membranous particles (30-1,000 nm in diameter) secreted by cells. Important biological functions have been attributed to 2 subsets of EV, the exosomes (bud from endosomal membranes) and the microvesicles (MV; bud from plasma membranes). Since both ...
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