Researchers at Vanderbilt University Medical Center have discovered a nanoparticle released from cells, called a “supermere,” which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease and even COVID-19. The discovery, reported Dec. 9 in Nature Cell ...
Read More »Reassessment of Exosome Composition
The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, researchers at the...
Read More »Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells
The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. Researchers from the Vanderbilt University Medical Center previously showed that...
Read More »Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting
Exosomes are small, 40-130 nm secreted extracellular vesicles that recently have become the subject of intense focus as agents of intercellular communication, disease biomarkers and potential vehicles for drug delivery. It is currently unknown whether a cell produces different populations ...
Read More »Directional cell movement through tissues is controlled by exosome secretion
Directional cell movement through tissues is critical for multiple biological processes and requires maintenance of polarity in the face of complex environmental cues. Here researchers from the Vanderbilt University Medical Center use intravital imaging to demonstrate that secretion of exosomes ...
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