Extracellular vesicles (EVs) are released from basically all cells. Over the last decade, small EVs (sEVs; 50-150 nm) have gained enormous attention in diagnostics and therapy. However, methodological limitations coupled to the lack of EV standards leave...
Read More »Ras and exosome signaling
Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream of Ras has shown limited ...
Read More »Commonly used drugs function through extracellular vesicles
Extracellular vesicles (EVs) are attractive candidates for biomarker research, because their content reflects the parental cell status. Researchers from the University Medical Center Utrecht examined whether tumor cell derived EVs mirrored the cellular changes caused by treatment with cetuximab, a ...
Read More »Extracellular vesicle production is higher in cells before adipogenesis
Extracellular vesicles (EVs) are submicron vesicles released from many cell types, including adipocytes. EVs are implicated in the pathogenesis of obesity-driven cardiovascular disease, although the characteristics of adipocyte-derived EVs are not well described. Researchers at Cardiff University sought to define ...
Read More »Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs
Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the ...
Read More »Vesicle vehicles of genetic information
from Nature Reviews Genetics Exosomes are a type of extracellular vesicle that can transfer cellular cargo between cells and have emerging importance in cell–cell communication. The exosome-mediated transfer of genetic information in the form of microRNAs (miRNAs) or mRNAs has ...
Read More »Microvesicles and exosomes for intracardiac communication
The heart is an organ with a complex mixture of well-organized interactions of different cell types that facilitate proper myocardial contractility, sufficient perfusion, balanced myocardial extracellular stiffness, and controlled functioning of the immune system. Several cell types, including cardiomyocytes, endothelial ...
Read More »Exploration of microRNAs in porcine milk exosomes
Breast milk contains complex nutrients and facilitates the maturation of various biological systems in infants. Exosomes, membranous vesicles of endocytic origin found in different body fluids such as milk, can mediate intercellular communication. Researchers at the South China Agricultural University hypothesized ...
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