The potential use of mitochondrial extracellular vesicles as biomarkers or therapeutical tools

The mitochondria play a crucial role in cellular metabolism, reactive oxygen species (ROS) production, and apoptosis. Aberrant mitochondria can cause severe damage to the cells, which have established a tight quality control for the mitochondria. This process avoids the accumulation of damaged mitochondria and can lead to the release of mitochondrial constituents to the extracellular milieu through mitochondrial extracellular vesicles (MitoEVs). These MitoEVs carry mtDNA, rRNA, tRNA, and protein complexes of the respiratory chain, and the largest MitoEVs can even transport whole mitochondria. Macrophages ultimately engulf these MitoEVs to undergo outsourced mitophagy. Recently, it has been reported that MitoEVs can also contain healthy mitochondria, whose function seems to be the rescue of stressed cells by restoring the loss of mitochondrial function. This mitochondrial transfer has opened the field of their use as potential disease biomarkers and therapeutic tools. Researchers at the University of Valencia describe this new EVs-mediated transfer of the mitochondria and the current application of MitoEVs in the clinical environment.

Graphical explanation of the potential therapeutic and diagnostic use
of large and small MitoEVs

Larger MitoEVs refer to EVs that are shed from the plasmatic membrane of the cell and can include whole mitochondria; these EVs are particularly interesting in the field of mitochondrial transfer as therapeutic vehicles. Small MitoEVs are included in MVB previous to their release and contain material from the mitochondrial origin (mtDNA and proteins); its analysis may serve as a diagnostic tool in liquid biopsies.

Jorge Sanz-Ros J, Mas-Bargues C, Romero-García N, Huete-Acevedo J, Dromant M, Borrás C . (2023) The Potential Use of Mitochondrial Extracellular Vesicles as Biomarkers or Therapeutical Tools. Int J Mol Sci 24(8), 7005. [article]

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