The significance of exosomes in the development and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common malignancy. Eoxsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC. Exosomes are small vesicular structures that mediate interaction between different types of cells, and contain a variety of components (including DNA, RNA, and proteins). Numerous studies have shown that these substances in exosomes are involved in growth, metastasis and angiogenesis in liver cancer, and then inhibited the growth of liver cancer by blocking the signaling pathway of liver cancer cells. In addition, the exosomal substances could also be used as markers for screening early liver cancer. Researchers from Capital Medical University summarize the significance of exosomes in the occurrence, development, diagnosis and treatment of HCC, which in turn might help us to further elucidate the mechanism of exosomes in HCC, and promote the use of exosomes in the clinical diagnosis and treatment of HCC.

The detailed mechanism of the role exosomes played in the process of CHB to HCC


a After infection with HBV, the viruses using exosomes secrete some substances that lead to chronic infection with HBV. b During the chronic infection with HBV, the viruses stimulate all kinds of cells to release exosomes, leading to liver cirrhosis (LC). c The concrete mechanism of exosomes during the formation of HCC

Li X, Li C, Zhang L, Wu M, Cao K, Jiang F, Chen D, Li N, Li W. (2020) The significance of exosomes in the development and treatment of hepatocellular carcinoma. Mol Cancer 19(1):1. [article]

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