Therapeutic Solutions International Licenses Dexosome Clinical Stage Cancer Immunotherapy Product

OCEANSIDE, CA–(Marketwired – January 25, 2016) – Therapeutic Solutions International, Inc., (OTC PINK: TSOI) announced today the signing of an exclusive intellectual property license agreement with Gustave Roussy Transfert of Villejuif, France for an issued U.S. patent covering the clinically tested “Dexosome” cancer immunotherapy product.

Dexosomes are exosome nanoparticles generated by dendritic cells, which have previously been used by investigators at Anosys, Inc., in collaboration with researchers at Duke University, for treatment of cancer patients as part of an FDA-cleared Phase I clinical trial(1). The licensed patent was invented by internationally-renowned immunologists Sebastian Amigorena, Doctor at the Curie Institute, and Laurence Zitvogel, Professor at Gustave Roussy. While the patent was issued when licensed to Anoysis, subsequent to merger between Anosys, Inc. and Epimmune, the patent was reverted to Gustave Roussy Transfert. The patent covers means of generating therapeutically-effective dexosomes, which can act as a platform for loading any tumor antigen desired.

“We are extremely fortunate to obtain this license of a technology in which clinical safety and proof-of-concept already exists,” said Timothy Dixon, President and CEO of TSOI. “In the area of drug development, much of the risk is taking the technology from the lab to the patient. We are fortunate that the current technology has already been utilized in patients under FDA jurisdiction, and has demonstrated safety with signs of efficacy.”

The in-licensing of the current patent augments previously filed patent applications by TSOI, including one filed in November 2015, covering uses of exosomes to stimulate both innate and adaptive arms of the immune response(2). The Company plans to leverage the experience of its newest Board Member, Dr. Thomas Ichim, to lead the Dexosome program back into clinical trials. Dr. Ichim has previously patented the manipulation of exosomes in the area of cancer therapy for alleviation of immune suppression(3), as well as being published in the peer-reviewed literature in this area(4)(5).

“Given that we are now living in the Golden Era of cancer immunotherapy, I am fortunate to be able to contribute my experiences in obtaining rapid clinical development of biologics, so that we may begin providing options to cancer patients, who previously had none,” said Thomas Ichim, Ph.D

About Therapeutic Solutions International, Inc.
The Company’s corporate website is Our new products can be viewed on and products can be ordered at

These Supplement products have not been evaluated by the United States Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any diseases.

About Gustave Roussy
Gustave Roussy is the premier European Cancer Centre. It is a centre for patient care, research and teaching, and patients with all types of cancer can be treated there. The Institute has expertise in the management of rare cancers and complex tumors. It treats all cancers at every stage of life. It offers its patients individualized care combining innovation and a humane approach. The treatment is important but so is quality of life, physical, psychological and social.

Gustave Roussy is a hospital for specialist referral of complex cases and rare tumors. It can bring to bear skills in medical oncology, chemotherapy, radiotherapy, surgery, interventional radiology and reconstructive surgery.

Source – EIN News

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