Exosomes are small extracellular nanovesicles that are released by cells, and their potential has been explored for use in cosmetics, skin care, tissue regeneration, and dermatological diseases. The therapeutic value of exosomes lies in their ability to modulate the microenvironment of cells, regulate gene expression, and induce cell differentiation, which can have a positive impact on skin health. In terms of cosmetics, exosomes have been used to reduce wrinkles, improve skin texture and hydration, and enhance skin elasticity, as well as to reduce inflammation and damage caused by UV radiation. Furthermore, exosomes have been used to promote tissue regeneration in skin wounds and to treat dermatological diseases such as systemic lupus erythematosus, psoriasis, atopic dermatitis, systemic sclerosis, pigment regulation, vitiligo, and hair growth. Researchers from the University of Chicago elaborate on the therapeutic value of exosomes in the field of cosmetics, skin care, tissue regeneration, and dermatological diseases. The existing literature demonstrated that with further research, exosomes may become a viable therapeutic option for many skin conditions.
Role of exosomes for anti-aging treatment
The administration of ASC-CM and BMSC-exos had the effect of decreasing the production of reactive oxygen species (ROS) to a low level, decreasing the expression of tumor necrosis factor-alpha (TNF-α) but increasing the expression of transforming growth factor-beta (TGF-β), leading to an increase in the production of matrix metalloproteinase-1 (MMP-1) and pro-collagen type I, which ultimately enhanced the synthesis of collagen in the skin, improving its elasticity and reducing the appearance of wrinkles, making it an effective anti-aging therapy. Figure was created using Biorender.