Exosome RNA Exosome RNA Research & Industry News
| Session Title: | Exosomes and Microvesicles in Cancer |
| Session Type: | Current Concepts in Diagnostics and Therapeutics Research |
| Session Start/End Time: | Tuesday, Apr 08, 2014, 1:00 PM – 3:00 PM |
| Location: | Room 11, San Diego Convention Center |
| CME: | CME-Designated |
| CME/CE Hours: | 2 |
| Session Description: | Exosomes and microvesicles are small spherical membrane fragments shed by various cell-types during physiological processes. Increasing attention has been focused on the role of exosomes and microparticles in malignant progression and metastasis. Recent studies have revealed selective packaging of proteins, lipids and genetic material, such as mRNAs, miRNAs, and DNA, into exosomes and microvesicles. Thus, exosomes can mediate the horizontal transfer of these functional molecules into recipient cells promoting their “education” in migration, angiogenesis and pro-metastatic properties. Many types of tumor cells can secrete large amounts of exosomes and microparticles in circulation. In this session, we will address the use of tumor exosomes and their particular signatures (i.e., proteins, lipids and genes) as potential biomarkers for prognostic and diagnostic means, as well as the possibility as targets for specific therapeutic development. We will address the complexities of identifying tumor exosomes and microparticles and their functional properties as compared to other stromal-derived particles in circulation. We will also compare the strengths of exosome and microparticle as unique biomarker |
| Chairperson Tuesday, Apr 08, 2014, 1:00 PM – 3:00 PM David C. Lyden. Weill Cornell Medical College of Cornell Univ., New York, NY |
| Tumor-derived exosomes promote pre-metastatic niche formation and organotropism Tuesday, Apr 08, 2014, 1:00 PM – 1:20 PM David C. Lyden. Weill Cornell Medical College of Cornell Univ., New York, NY |
| Discussion Tuesday, Apr 08, 2014, 1:20 PM – 1:25 PM |
| Functional analysis of lipidome profile alterations in malignant and metastatic colon adenocarcinoma cell derived exosomes Tuesday, Apr 08, 2014, 1:25 PM – 1:45 PM Gavin E. Reid. Michigan University, East Lansing, MI |
| Discussion Tuesday, Apr 08, 2014, 1:45 PM – 1:50 PM |
| Exosome Mobilization of Planar Cell Polarity Signalling in Cell Motility and Metastasis Tuesday, Apr 08, 2014, 1:50 PM – 2:10 PM Jeffrey L. Wrana. Samuel Lunenfeld Research Institute, Toronto, ON, Canada |
| Discussion Tuesday, Apr 08, 2014, 2:10 PM – 2:15 PM |
| Effect of mutant KRAS on composition and behavior of exosomes in colorectal cancer Tuesday, Apr 08, 2014, 2:15 PM – 2:35 PM Robert J. Coffey Jr.. Vanderbilt Univ. Medical Ctr., Nashville, TN |
| Discussion Tuesday, Apr 08, 2014, 2:35 PM – 2:40 PM |
| Panel Discussion Tuesday, Apr 08, 2014, 2:40 PM – 3:00 PM |
