Webinar tomorrow – Tracking and Monitoring Extracellular Vesicles in vivo

Tracking and Monitoring Extracellular Vesicles (EVs) in vivo: Overcoming High Background and Low Specificity

Wed, Jul 25, 2018 12:00 PM – 12:30 PM CDT

Exosomes and other extracellular vesicles (EVs) are a rapidly expanding area of study that encompasses a wide range of applications – from basic research to biomarker discovery to therapeutic delivery. EVs transport a valuable cargo of RNA, proteins, and lipids from one cell to another and have been shown to be involved in a wide range of physiological and pathogenic processes. Assessing the physiological impact of EVs either in vitro or in vivo has become a routine experiment in many EV-research focused labs. At the same time, research into the use of EVs as a delivery tool for therapeutic purposes has increased steeply. Both of these research approaches necessitate the ability to visualize EVs. Whereas there is a myriad of options for in vitro EV tracking, that is not the case for in vivo applications. High background from auto-fluorescence and lack of specificity are the two main technical challenges to overcome when trying to label EVs for in vivo tracking in full organisms. This webinar will illustrate how SBI’s latest EV labelling reagent, ExoGlow-Vivo, swiftly overcomes the challenges that exist when performing in vivo tracking. A near-IR dye, ExoGlow-Vivo is designed to track EVs in vivo with high specificity and sensitivity, making it ideal for EV biodistribution and kinetic studies that are key to both basic research and translational applications.


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